Antibody Concentration Measurement Using Optical Rotation: Toward Process Analytical Technology
نویسندگان
چکیده
The antibody manufacturing process consists of the cell culture using animal cells and purification including several chromatography steps filtration steps. is important to obtain high quality bio-pharmaceutical products by removing impurities, measurement concentrations a fundamental essential factor control confirm yield each step. Here we introduce optical rotation method as resolution for measuring in process. Feasibility evaluation showed that applicable wide range even supernatants containing various contaminants. In addition, examples application analytical technology, show possibility continuous process, tangential flow concentration
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ژورنال
عنوان ژورنال: MATEC web of conferences
سال: 2021
ISSN: ['2261-236X', '2274-7214']
DOI: https://doi.org/10.1051/matecconf/202133315002